Effect of static magnetic field on development toxicity of rat embryonic midbrain neurons cells.
- Author:
Li-rong DUAN
1
;
Quan-yi WU
;
Fang-ping LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Differentiation; radiation effects; Cell Division; radiation effects; Cells, Cultured; Electromagnetic Fields; adverse effects; Embryo, Mammalian; Female; Lipid Peroxidation; radiation effects; Mesencephalon; cytology; radiation effects; Neurons; cytology; radiation effects; Protein Biosynthesis; radiation effects; Rats; Rats, Sprague-Dawley
- From: Chinese Journal of Preventive Medicine 2004;38(3):190-192
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effect of static magnetic field (SMF) on the differentiation and proliferation of rat embryonic midbrain neurons cells.
METHODSThe micromass culture of rat embryonic midbrain neurons cell was applied to study the effect of varieties of SMF (1.0, 10.0, 50.0, 100.0, 200.0 mT) and FACS.
RESULTSSMF inhibited the differentiation of the cell without affecting cell proliferation. The concentration of 50% inhibition of cell differentiation (ICD(50)) was 25 mT. The concentration of 50% inhibition of cell differentiation (IVD(50)) was 45 mT.
CONCLUSIONSThe inhibition of SMF on embryonic midbrain neurons cells may be associated with impact of protein syntheses, and lipid peroxidation.
