A study on the factors influencing insulin resistance in children and adolescents.
- Author:
Ying LI
1
;
Chang-Hao SUN
;
Ying WEN
;
Wen-Xiu CUI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Body Mass Index; Child; Estradiol; blood; Growth Hormone; metabolism; Humans; Insulin; blood; Insulin Resistance; Leptin; blood; physiology; Male; Malnutrition; blood; Obesity; blood; physiopathology; Puberty; physiology; Testosterone; blood
- From: Chinese Journal of Preventive Medicine 2004;38(4):234-236
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the factors influencing insulin resistance in children with different nutritional status during pubertal development.
METHODSThree hundred children with simple obese aged 7 to 17 years, and 300 normal healthy children and 300 children with malnutrition, matched for age (+/- 3 months) and height (+/- 2 cm), were selected. Fasting serum levels of leptin, insulin, glucose, total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) were measured for them.
RESULTSLevels of fasting serum insulin in obese children, except for boys at Tanner stage I and girls at Tanner stage II, were higher than those in normal and malnutrition children (P < 0.01). Average serum level of leptin in obese boys and girls at varied Tanner stages was higher than that in normal children, and higher in normal children than that in children with malnutrition (P<0.01). Serum level of TG in obese children [(1.53 +/- 0.13) mmol/L] was higher than that in normal ones [(1.12 +/- 0.10) mmol/L] and in children with malnutrition [(1.03 +/- 0.09) mmol/L]. There was no significant difference in levels of fasting blood glucose and other blood lipids between the three groups of children. Insulin sensitivity decreased with pubertal development and its index reversely correlated with Tanner stage and serum level of leptin (r=-0.27 and -0.36, respectively, P<0.01).
CONCLUSIONObesity (BMI), serum level of leptin and pubertal development were independent risk factors for insulin resistance in children aged 7 to 17 years.