Association study of LIS1 and TSNAX genes with bipolar disorder in Chinese Han population.

Xuan LI; Lijie Guan; Yin Lin; Xiaofei Zhang; Wenhao Deng; Zhenxing Yang; Xiaohong MA; Guohui Lao; Biyu YE; Weijie Huang; Zeyu Jiang; Guodong Miao; Guiyun XU; Wentao Liu; Yingcheng Wang; Tao LI; Liping Cao

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Association study of LIS1 and TSNAX genes with bipolar disorder in Chinese Han population.

VernacularTitle:LIS1和TSNAX基因与中国汉族人群双相障碍Ⅰ型的关联研究
Author: Xuan LI ¹ ; Lijie GUAN ; Yin LIN ; Xiaofei ZHANG ; Wenhao DENG ; Zhenxing YANG ; Xiaohong MA ; Guohui LAO ; Biyu YE ; Weijie HUANG ; Zeyu JIANG ; Guodong MIAO ; Guiyun XU ; Wentao LIU ; Yingcheng WANG ; Tao LI ; Liping CAO
Author Information

1. Early Intervention Department of Guangzhou Brain Hospital Affiliated to Guangzhou Medical University, Guangzhou, Guangdong 510370, P. R. China. Email: coolliping@hotmail.com.
Publication Type:Journal Article
MeSH: 1-Alkyl-2-acetylglycerophosphocholine Esterase; genetics; Adolescent; Adult; Aged; Aged, 80 and over; Asian Continental Ancestry Group; ethnology; genetics; Bipolar Disorder; ethnology; genetics; Case-Control Studies; DNA-Binding Proteins; genetics; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; Microtubule-Associated Proteins; genetics; Middle Aged; Polymorphism, Single Nucleotide; Young Adult
From: Chinese Journal of Medical Genetics 2014;31(3):357-361
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo assess the association of neural development-related genes LIS1and TSNAX with bipolar disorder in a Chinese Han population.
METHODSThree hundred and eight five patients (including 188 males and 197 females) from Guangzhou Brain Hospital with bipolar disorder meeting the Diagnostic and Statistic Manual of Bipolar Disorder (BDI) (Fourth Edition) criteria and 475 healthy controls from the local community were recruited. Ten single nucleotide polymorphisms (SNPs) of the LIS1 and TSNAX genes were genotyped by GoldenGate genotyping assay on an Illumina Beadstation 500 machine. Association analyses of SNPs and haplotypes were performed with Plink 1.07 software.
RESULTSAnalysis of the total sample has failed to find any association of SNP or haplotype of the two genes with BDI (P> 0.05). When patients were divided into subgroups with or without psychotic symptom, no significant association of the two genes was found with psychotic BDI or non-psychotic BDI (P> 0.05). No significant association was found between any SNP and haplotype of two genes and female BDI or male BDI, nor were significant association found between age of onset and LIS1 and TSNAX gene polymorphisms.
CONCLUSIONOur results indicated that LIS1 and TSNAX genes are not associated with susceptibility to bipolar I disorder in Chinese Han population.