Impact of six genetic polymorphisms on Warfarin maintenance dose variation in Chinese Han population.
- Author:
Ying LOU
1
;
Lulu HAN
;
Yan LI
;
Xiaoxing ZHANG
;
Zhihong LIU
;
Min TANG
;
Haiwen YU
;
Wei WANG
;
Jianping XU
;
Hong LIU
;
Yishi LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aryl Hydrocarbon Hydroxylases; genetics; Asian Continental Ancestry Group; ethnology; genetics; Atrial Fibrillation; drug therapy; ethnology; genetics; Cytochrome P-450 CYP2C9; Cytochrome P-450 Enzyme System; genetics; Cytochrome P450 Family 4; Dose-Response Relationship, Drug; Epoxide Hydrolases; genetics; Female; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Protein C; genetics; Pulmonary Embolism; drug therapy; ethnology; genetics; Treatment Outcome; Vitamin K Epoxide Reductases; genetics; Warfarin; administration & dosage; Young Adult
- From: Chinese Journal of Medical Genetics 2014;31(3):367-371
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effect of VKORC1, CYP2C9, GGCX, PROC, EPHX1 and CYP4F2 gene polymorphisms on Warfarin maintenance dose variation in Chinese Han Population.
METHODSFour hundred eighty-eight patients with prosthetic heart valves, atrial fibrillation or pulmonary thromboembolism and achieved stable Warfarin dose were enrolled. TaqMan probe or direct sequencing were used to genotype Y9VKORC1, CYP2C9, GGCX, EPHX1 and CYP4F2 gene polymorphisms. Demographic characteristics, stable therapeutic dose of Warfarin and concomitant medications were collected for all patients. The effect of VKORC1, CYP2C9, GGCX, PROC, EPHX1 and CYP4F2 gene polymorphisms, demographic characteristics and concomitant medications on Warfarin daily maintenance dose were analyzed with statistical method.
RESULTSVKORC1 and CYP2C9 gene polymorphisms could explain more than 50% Warfarin maintenance dose variation in recruited patients, while CYP4F2 gene polymorphisms could only explain 1%. GGCX, PROC and EPHX1 gene polymorphisms had no impact no Warfarin maintenance dose. VKORC1 and CYP2C9 gene polymorphisms have a greater impact on Warfarin maintenance dose compared with demographic characteristics and concomitant medications.
CONCLUSIONVKORC1 and CYP2C9 gene polymorphisms have a significant impact on Warfarin maintenance dose in Chinese Han population.
