Value of second-time invasive prenatal diagnosis in the current circumstances.
- Author:
Yi WU
1
;
Yanlin WANG
;
Weiwei CHENG
;
Jingbo YU
;
Chunmin LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Amniocentesis; Female; Fetal Diseases; diagnosis; genetics; Humans; Karyotyping; methods; Middle Aged; Pregnancy; Prenatal Diagnosis; methods; Trisomy; Young Adult
- From: Chinese Journal of Medical Genetics 2014;31(3):376-379
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the safety of repeated invasive prenatal diagnosis primarily due to failed culture of amniotic cells.
METHODSBetween January 2000 and October 2012, 167 cases required repeated invasive prenatal diagnosis among a total of 5304 amniocentesis cases. Clinical outcome and karyotypes were analyzed to calculate the rate of fetal loss.
RESULTSFor the 167 re-sampled cases, the indications have included failed amniocyte culture (121 cases), chromosome mosaicisms (23 cases), failed amniocentesis (21 cases), and request for confirmation (2 cases). No fetal loss has occurred. All samples were cultured successfully. Fourteen cases (8.38%) have been found with an abnormal karyotype. Four mosaic trisomic cases (2 mosaic trisomy 16, 1 mosaic trisomy 20, and 1 mosaic trisomy 8) were verified to be normal.
CONCLUSIONRepeated invasive prenatal diagnosis does not increase the rate of fetal loss. It can be recommended to cases with failed amniocyte culture. Caution should be undertaken when counseling prenatally detected mosaicism trisomies.
