Predictive value of HLA-DRB1 gene for the treatment of unexplained recurrent spontaneous abortion with paternal lymphocyte alloimmunization therapy in Henan Hans.
- Author:
Ke YANG
1
;
Bing ZHANG
;
Shixiu LIAO
;
Miao HE
;
Yan CHU
;
Qiancheng LI
;
Qiannan GUO
;
Qiaofang HOU
;
Xuebing DING
Author Information
- Publication Type:Clinical Trial
- MeSH: Abortion, Spontaneous; ethnology; genetics; immunology; therapy; Asian Continental Ancestry Group; ethnology; genetics; China; Female; Genetic Predisposition to Disease; ethnology; HLA-DRB1 Chains; genetics; Humans; Immunotherapy; Isoantigens; immunology; Lymphocytes; immunology; Male; Pregnancy; Treatment Outcome
- From: Chinese Journal of Medical Genetics 2014;31(3):380-382
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the value of HLA-DRB1 gene in predicting the outcome of unexplained recurrent spontaneous abortion (URSA) treated with paternal lymphocyte alloimmunization therapy (PLAT) in Henan Hans.
METHODSThree hundred URSA patients were recruited. Following PLAT treatment, they were divided into two groups according to the outcome of pregnancy. Polymerase chain reaction sequence specific primer (PCR-SSP) were conducted to analyze the HLA-DRB1 gene.
RESULTSFor those who have received PLAT treatment, the frequency of HLA-DRB1*11 was significantly lower in successfully treated cases than those with abortion (0.052 vs. 0.110, P < 0.05, OR=0448), whilst the frequency of HLA-DRB1*15 was significantly greater in the former (0.207 vs. 0.100, P < 0.05, OR=2.352).
CONCLUSIONFor patients who have received PLAT treatment, those with HLA-DRB1*15 are more likely to conceive that those with HLA-DRB1*11.
