Association of CMA1 gene tag single nucleotide polymorphisms with essential hypertension in Yi population from Yunnan.
- Author:
Yanrui WU
1
;
Qian LI
;
Ke YANG
;
Chunjie XIAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Alleles; Asian Continental Ancestry Group; ethnology; genetics; Blood Pressure; China; ethnology; Chymases; genetics; Essential Hypertension; Female; Humans; Hypertension; ethnology; genetics; physiopathology; Male; Middle Aged; Polymorphism, Single Nucleotide
- From: Chinese Journal of Medical Genetics 2014;31(4):449-454
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of tag single nucleotide polymorphisms (tag SNPs) of chymase gene (CMA1) with essential hypertension in Yi population from Yunnan, China.
METHODSA case-control study was carried out. Four tag SNPs(rs1956921, rs1800876, rs5244 and rs1885108) were genotyped in 303 patients with essential hypertension and 312 healthy controls using polymerase chain reaction - restriction fragment length polymorphism(PCR-RFLP) method.
RESULTSNo significant difference in genotypic and allelic distributions of the four polymorphisms was detected between the two groups(P>0.05), and the same results existed in the females. The frequencies of rs1956921 C allele and a C-T haplotype constructed with rs1956921 and rs5244 were greater in male patients compared with male controls(P<0.01).
CONCLUSIONThe rs1956921 C allele of the CMA1 gene and the C-T haplotype constructed with rs1956921 and rs5244 may be risk factors for essential hypertension in ethnic Yi males from Yunnan.
