Association of TLR4 gene polymorphisms with large artery atherosclerotic stroke and vascular bed selectivity of atherosclerotic lesions.
- Author:
Xiang XU
1
;
Na NA
;
Xudong PAN
;
Kun WANG
;
Aijun MA
;
Yuan WANG
;
Li WANG
;
Runze ZHOU
;
Guomei ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Asian Continental Ancestry Group; ethnology; genetics; Base Sequence; Coronary Artery Disease; ethnology; genetics; pathology; Coronary Vessels; pathology; Female; Genetic Association Studies; Humans; Male; Middle Aged; Molecular Sequence Data; Polymorphism, Single Nucleotide; Stroke; ethnology; genetics; pathology; Toll-Like Receptor 4; genetics
- From: Chinese Journal of Medical Genetics 2014;31(4):455-461
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of TLR4 gene polymorphisms with large artery atherosclerosis (LAA) stroke and liability to atherosclerosis in an ethnic Han population from northern China.
METHODSThe study has involved 286 LAA stroke patients and 300 healthy controls. The LAA group has been divided 4 subsets according to angiostenosis conditions. Polymerase chain reaction-restriction fragment length polymorphism and pyrosequencing were employed to analyze three single nucleotide polymorphism (SNPs) (rs1927914, rs1927911 and rs2149356) of the TLR4 gene. A Haploview software package was used to analyze the haplotypes.
RESULTSSNPs rs1927911 and rs2149356 were associated with LAA stroke. Genotypic and allelic frequencies of rs1927914 did not differ significantly between the two groups. Genetic variants of the three SNPs did not vary significantly between all subsets. Haplotype analysis was revealed a significant difference between the LAA group and the control group. Compared with the controls, the frequencies of haplotypes H2 and H8 were lower, and that of H3 was greater in the LAA group.
CONCLUSIONAn association between the TLR4 gene polymorphisms and LAA stroke subtype in ethnic Han population in northern China has been found. However, no association of liability to atherosclerosis in different vascular bed has been found with these polymorphisms.
