Association of polymorphisms of HLA-DRB1 gene with unexplained recurrent spontaneous abortion in ethnic Hans from Henan.
- VernacularTitle:河南地区汉族人群原因不明复发性流产与HLA-DRB1等位基因多态性的相关性
- Author:
Miao HE
1
;
Bing KANG
;
Shixiu LIAO
;
Ke YANG
;
Xuebing DING
;
Dong WU
;
Qiannan GUO
;
Qiaofang HOU
Author Information
- Publication Type:Journal Article
- MeSH: Abortion, Spontaneous; ethnology; genetics; Alleles; Asian Continental Ancestry Group; ethnology; genetics; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; HLA-DRB1 Chains; genetics; Humans; Male; Polymorphism, Single Nucleotide; Pregnancy; Young Adult
- From: Chinese Journal of Medical Genetics 2014;31(4):504-507
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of polymorphisms of human leukocyte antigen DRB1 gene (HLA-DRB1) with susceptibility to unexplained recurrent spontaneous abortion (URSA).
METHODSThe HLA-DRB1 gene was typed with polymerase chain reaction-specific sequence primers (PCR-SSP) method in 200 couples with URSA and 200 couples with a normal pregnancy history.
RESULTSThe frequencies of DRB1*09 and DRB1*13 alleles were significantly greater in the URSA group compared with the control group (14.50% vs. 9.50%, and 7.00% vs. 4.38%, both P<0.05), whilst the frequencies of DRB1*04 and DRB1*12 alleles were significantly lower (7.13% vs. 10.75%, and 8.63% vs. 14.38%, both P<0.05). For females from the URSA group, the frequency of DRB1*09 allele (14.00%) was significantly higher compared with the controls (9.25%) (P=0.036), whilst the frequency of DRB1*12(8.50%) allele was significantly lower (14.00%) (P=0.014). For males in the URSA group, the frequencies of DRB1*09 and DRB1*13 alleles were significantly higher than those of the controls (15.00% vs. 9.75%, and 9.25% vs. 4.00%, both P<0.05), whilst the frequencies of DRB1*04 and DRB1*12 alleles were significantly lower (5.75% vs. 12.25%, and 8.75% vs. 14.75%, P<0.05).
CONCLUSIONThe DRB1*09 and DRB1*13 alleles may contribute to the susceptibility of URSA, while DRB1*04 and DRB1*12 alleles may confer a protective effect factors. For females, however, no significant association of DRB1*13 and DRB1*04 alleles with URSA was found.
