Clinical and genetics characteristics of patients with monosomal karyotype acute myeloid leukemia patients.
- Author:
Feng CHENG
1
;
Xiaolin MA
;
Jinlan PAN
;
Yafang WU
;
Jun ZHANG
;
Yongquan XUE
;
Qinrong WANG
;
Hong YAO
;
Lijun WEN
;
Yunfeng SHEN
;
Suning CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Chromosomes, Human, Pair 7; genetics; Female; Humans; Karyotype; Leukemia, Myeloid, Acute; genetics; Male; Middle Aged; Monosomy; Young Adult
- From: Chinese Journal of Medical Genetics 2014;31(4):508-510
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinical and genetics characteristics of patients with monosomal karyotype acute myeloid leukemia (MK-AML).
METHODSThe karyotypes of 3743 patients with newly-diagnosed de novo AML were analyzed, which had identified 153 cases with MK-AML, for whom the clinical and genetics characteristics were analyzed.
RESULTSThere were 2056 patients (54.9%) among all patients. A total of 153 patients fulfilling the criteria for MK-AML were identified, which comprised 93 males and 60 females, with a median age of 54. The median white blood cell count on presentation was 4.4×10 (9)/L. One hundred and forty-five cases (94.8%) have fulfilled the criteria for complex karyotype (≥ 3 chromosomal abnormalities). Although the monosomy could be found with all autosomes, chromosome 7 has been most frequently involved (38.56%, 59/153).
CONCLUSIONMK-AML is a distinct cytogenetic subtype of AML. Monosomy 7 is frequently detected among MK-AML patients. The monosomal karyotype is common among elder patients with AML.
