Identification of a novel allele HLA-B*37:04:02.
- VernacularTitle:新等位基因HLA-B*37:04:02的序列分析
- Author:
Xiaofeng LI
1
;
Xu ZHANG
;
Kunlian ZHANG
;
Fengqiu LIN
;
Jianping LI
Author Information
- Publication Type:Case Reports
- MeSH: Alleles; Asian Continental Ancestry Group; genetics; Base Sequence; Genotype; HLA-B Antigens; genetics; Humans; Molecular Sequence Data
- From: Chinese Journal of Medical Genetics 2014;31(4):515-517
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo report on a novel HLA allele identified in a Chinese individual.
METHODSRoutine HLA genotyping was carried out with polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) and sequencing-based typing (SBT).
RESULTSA new HLA allele has been identified. The sequence differed from its closest allele B*37:04:01 at nt618 (GCG→GCA), which resulted in no change of codon 206.
CONCLUSIONA novel HLA allele HLA-B*37:04:02 (GU391034) has been identified and officially named by the WHO Nomenclature Committee.
