Significance of BCL6, MYC, P53 genes abnormalities for the prognosis of diffuse large B-cell lymphoma.
- VernacularTitle:HLA新等位基因A*33:44序列分析
- Author:
Panke GAO
1
;
Qing LI
;
Zhilin WANG
;
Feng YAN
;
Changqing LU
;
Xiangshan CAO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; DNA-Binding Proteins; genetics; Female; Gene Deletion; Gene Rearrangement; Humans; In Situ Hybridization, Fluorescence; Lymphoma, Large B-Cell, Diffuse; diagnosis; genetics; mortality; Male; Middle Aged; Mutation; Prognosis; Proto-Oncogene Proteins c-bcl-6; Proto-Oncogene Proteins c-myc; genetics; Survival Analysis; Survival Rate; Tumor Suppressor Protein p53; genetics; Young Adult
- From: Chinese Journal of Medical Genetics 2014;31(5):628-631
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the influence of BCL6, MYC, P53 genes abnormalities can on the prognosis of diffuse large B-cell lymphoma (DLBCL), and to identify independent prognostic factors for DLBCL in order to facilitate clinical prognosis and selection of stratification treatment for the patients.
METHODSSixty five newly diagnosed DLBCL pathological specimens were collected from 2009 to 2012. Interphase fluorescence in situ hybridization technique (I-FISH) was used to detect the status of BCL6, MYC and P53 genes. Clinical factors were combined with immunohistochemical results for multiple-factor survival analysis.
RESULTSThe rates of BCL6 gene rearrangement, P53 gene deletion and MYC rearrangement were 21.5% (14/65), 35.4% (23/65) and 7.7% (5/65), respectively. BCL6 rearrangement group has obviously poorer overall survival (OS)(P< 0.05). COX proportional hazards model analysis showed that gender, BCL6 protein, BCL6 rearrangement, Ki67 index were prognosis factors independent of international prognostic index (IPI).
CONCLUSIONBCL6 can influence the prognosis of patients with DLBCL at gene and protein levels and both are independent prognostic factors for DLBCL.
