Studies on the association of single nucleotide polymorphisms of HLA-DP and DQ genes with the outcome of chronic hepatitis B virus infection.
- Author:
Mingkuan SU
1
;
Yongbin ZENG
;
Jing CHEN
;
Ling JIANG
;
Tianbin CHEN
;
Can LIU
;
Bin YANG
;
Qishui OU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Asian Continental Ancestry Group; ethnology; genetics; Case-Control Studies; China; ethnology; Female; Genotype; HLA-DP Antigens; genetics; HLA-DQ Antigens; genetics; Hepatitis B virus; physiology; Hepatitis B, Chronic; ethnology; genetics; virology; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide
- From: Chinese Journal of Medical Genetics 2014;31(6):765-769
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of single nucleotide polymorphisms in the HLA-DP and DQ genes with the outcome of chronic hepatitis B virus infection.
METHODSTwo hundred and four healthy subjects, 255 clearance subjects, 204 asymptomatic HBV carriers (AsC), 136 chronic hepatitis B (CHB), 68 liver cirrhosis (LC) and hepatocellular carcinoma (HCC) were enrolled. Genotypes of rs3077, rs9277535 and rs2647050 were determined by sequence specific primers-PCR (PCR-SSP).
RESULTSBy using healthy subjects and clearance subjects as the control groups, rs3077 and rs9277535 were significantly associated with chronic HBV infection under additive and dominant models (P< 0.05). Meanwhile, haplotypes GGA, AGA, AAA appeared to be protective factors against chronic HBV infection (P < 0.05). By using AsC as the control group, comparison with the CHB, LC and HCC groups showed no association of the 3 SNPs or haplotypes with the clinical outcome (P > 0.05).
CONCLUSIONHLA-DP gene polymorphisms are strongly associated with chronic HBV infection. The presence of A allele at rs3077 and rs9277535 of the HLA-DP gene may decreased the risk for chronic HBV infection.
