Prevalence and correlates of herpes simplex virus infections among AIDS patients in a county of Shanxi province, China.
- Author:
Li CHEN
1
;
Qing-hai YANG
;
Shao-liang DONG
;
Jun WEI
;
Wang-qian JIA
;
Shu-xia QU
;
Xiao-chun QIAO
;
Na HE
Author Information
- Publication Type:Journal Article
- MeSH: Acquired Immunodeficiency Syndrome; complications; epidemiology; virology; Adolescent; Adult; Child; China; epidemiology; Female; Herpes Simplex; complications; epidemiology; Herpesvirus 1, Human; Herpesvirus 2, Human; Humans; Logistic Models; Male; Middle Aged; Prevalence; Risk Factors; Rural Population; Young Adult
- From: Chinese Journal of Preventive Medicine 2010;44(6):526-530
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the prevalence of herpes simplex virus (HSV) and its correlates among HIV/AIDS patients in a county of Shanxi.
METHODSAll HIV-infected patients in a county in Shanxi province who were receiving antiretroviral treatment (ART) were included in this study. Participants were interviewed using standard questionnaires. Serum samples were tested to determine HSV-1 and HSV-2 infections.
RESULTSA total of 195 AIDS patients were recruited and 195 blood samples were collected. Among 195 AIDS patients, 189 (96.9%) were farmers; 116 (59.5%) were men while 79 were women; 146 (74.9%) were between 20 - 50 years old; 180 (92.3%) were married. The major routes of HIV transmission were blood/plasma donation or transfusion (176 patients, 90.3%). CD(4)(+) T cell counts were between (1 - 1531) × 10(6) cells/L ((323.6 ± 14.8) × 10(6) cells/L), with 44 (26.5%) patients' CD(4)(+) T cell counts less than 200 × 10(6) cells/L. Of which, 154 patients (79.0%) had sexual partners. 86.8% (118 patients) consistently used condoms during the past 6 months, while for the last sexual act, 91.8% (123 patients) used condoms. For anti-HSV-1 status, there were about 164 patients (84.1%) were positive, and 26 (13.3%) were positive for anti-HSV-2. While, 14 (7.2%) were positive for both anti-HSV-1 and anti-HSV-2. Logistic regression analysis indicated that marital status were correlated with HSV-2 infection (OR = 7.41; 95%CI: 2.42 - 22.73; P < 0.01). No socio-demographic and sexual characteristics were identified to be correlated with HSV-1 infection.
CONCLUSIONA substantial proportion of AIDS patients in a rural county of Shanxi province of China were co-infected with HSV-1 and/or HSV-2. Marital status was correlated with HSV-2 infection.
