Expression of BP1 gene in adult acute leukemia.
- Author:
Hui LI
1
;
Kai-lin XU
;
Xiu-ying PAN
;
Hai-yan WANG
;
Zhen-yu LI
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Adolescent; Adult; Female; Genes, Homeobox; Globins; genetics; Homeodomain Proteins; genetics; Humans; Leukemia; genetics; Male; Middle Aged; Transcription Factors; genetics
- From: Chinese Journal of Hematology 2004;25(1):38-40
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the expression of beta protein 1 (BP1) gene in adult acute leukemia (AL) and its relationship with acute leukemia.
METHODSExpression of BP1 gene mRNA was detected in 70 adult AL, 10 normal controls and HEL cell line, by reverse transcriptase-polymerase chain reaction (RT-PCR).
RESULTSNo detectable BP1 gene was found in peripheral blood or bone marrow cells of normal controls and 20 acute myeloid leukemia (AML) in complete remission (CR) stage. BP1 gene was highly expressed in HEL cell line, 57% (20/35) of AML and 80% (8/10) of AML-M(5) cases. BP1 gene could not be detected in adult acute lymphoid leukemia.
CONCLUSIONBP1 gene was highly expressed in AML. It might be used as a molecular marker of AML.
