Detection of TCR-gamma chain gene rearrangement in malignant histiocytosis.
- Author:
Chang-li LU
1
;
Gan-di LI
;
Wei-ping LIU
;
Jia GUO
;
Feng-yuan LI
;
Dian-ying LIAO
;
Wen-yan ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Aged, 80 and over; CD56 Antigen; analysis; Child; Child, Preschool; Female; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; Histiocytosis; genetics; immunology; Humans; Infant; Male; Middle Aged; Polymerase Chain Reaction
- From: Chinese Journal of Hematology 2004;25(4):220-222
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the lineage of the malignant cells in malignant histiocytosis.
METHODSPolymerase chain reaction with two groups of common primers for TCR-gamma gene was used to analyze the malignant cells of 28 autopsied cases of malignant histiocytosis.
RESULTSMonoclonal TCR-gamma gene rearrangements were detected in 12 out of the 28 samples (43%).
CONCLUSIONMost cases diagnosed as malignant histiocytosis in Southwest China seems to be peripheral T-cell lymphomas.
