Advance in studies on anti-tumor mechanism of matrine.
- Author:
Lin-Feng GUO
1
;
Shan-Shan TONG
1
;
Jiang-Nan YU
1
;
Xi-Ming XU
1
Author Information
1. School of Pharmacy, Jiangsu University, Zhenjiang 212013, China.
- Publication Type:Journal Article
- MeSH:
Alkaloids;
pharmacology;
Animals;
Antineoplastic Agents, Phytogenic;
pharmacology;
Cell Cycle;
drug effects;
Cell Proliferation;
drug effects;
Gene Expression Regulation, Neoplastic;
drug effects;
Humans;
Neoplasms;
drug therapy;
genetics;
metabolism;
Quinolizines;
pharmacology
- From:
China Journal of Chinese Materia Medica
2013;38(20):3409-3412
- CountryChina
- Language:Chinese
-
Abstract:
Matrine is one of the main active components extracted from Sophora flavescens, S. subprostrata and S. alopecuroides. In recent years, its anti-tumor activity has attracted wide attention. According to studies, matrine shows the anti-tumor effect through multiple channels such as inducing apoptosis and autophagy of cancer cells, arresting cell cycle, inhibiting tumor cell migration, angiogenesis and NF-kappaB, as well as the synergistic effect with chemotherapeutics. Along with the further studies on matrine's anti-tumor mechanism, it has a broad prospect for development and application in tumor clinical treatment.
