Correlation between dissolution in vitro and absorption in vivo of chuanping sustained release tablets.
- Author:
Yan-Qu CAI
1
;
Zhi-Peng ZHANG
2
;
Yan-Hong WU
3
;
Jing LIU
3
;
Ji-Fu XIE
3
;
Jin-Zhen CHAI
3
;
Yu LUO
3
;
Sheng-Shan ZHU
3
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Chromatography, High Pressure Liquid; Delayed-Action Preparations; pharmacokinetics; Drugs, Chinese Herbal; administration & dosage; pharmacokinetics; Ephedrine; administration & dosage; pharmacokinetics; Female; Humans; Male; Solubility; Tablets; chemistry; Young Adult
- From: China Journal of Chinese Materia Medica 2013;38(20):3473-3478
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the correlation between dissolution in vitro and absorption in vivo of Chuanping sustained release tablets.
METHODThe ephedrine, pseudoephedrine were chosen as marker components, dissolution in vitro of Chuanping sustained release tablets in the different pH were tested by the rotating basket method and HPLC; urine drug levels were determined by HPLC and absorption fractions were calculated according to Wagner-Nelson's formula and deconvolution technique.
RESULTThe linear regressive equation between the absorption percentage in vivo F and accumulative release percentage in vitro of Chuanping sustained release tablets was established as F(ephedrine) = 1.572 5f-20. 729 (R2 = 0.974 5); F(pseudoephedrine) = 1.237f-0.147 6 (R2 = 0.959 5).
CONCLUSIONThe results suggested that there was fine correlation between the absorption percentage in vivo and the accumulative release percentage in vitro of Chuanping sustained release tablets.
