Effect of Jiangzhi Kangyanghua mixture on high-sensitivity C-reactive protein and vascular endothelial functions of hypertension patients.
- Author:
Wei-Dong QIAN
1
;
Zhu-Yuan FANG
2
;
Wei-Min JIANG
2
;
Hai-Ting LU
3
Author Information
1. Nanjing University of Traditional Chinese Medicine, Nanjing 210046, China. qwd213161@163.com
2. Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China.
3. Changzhou Wujin Hospital of Traditional Chinese Medicine, Changzhou 213161, China.
- Publication Type:Journal Article
- MeSH:
Aged;
Antihypertensive Agents;
administration & dosage;
Blood Pressure;
drug effects;
C-Reactive Protein;
metabolism;
Drugs, Chinese Herbal;
administration & dosage;
Endothelin-1;
metabolism;
Endothelium, Vascular;
drug effects;
physiopathology;
Female;
Humans;
Hypertension;
drug therapy;
metabolism;
physiopathology;
Male;
Middle Aged
- From:
China Journal of Chinese Materia Medica
2013;38(20):3583-3586
- CountryChina
- Language:Chinese
-
Abstract:
To observe the effect of Jiangzhikangyanghua Mixture on high-sensitivity CRP (hs-CRP) and vascular endothelial functions of essential hypertension (EH) patients. In this study, 72 cases of out-patients with EH were selected from department of cardiology of Wujin hospital of traditional Chinese Medicine, and randomly divided into the control group (n= 36, amlodipine 5 mg qd + valsartan 80 mg qd) and the test group (n =36 amlodipine 5 mg qd + valsartan 80 mg qd + Jiangzhikangyanghua mixture 20 mL tid). The contents of hs-CRP, ET-1 and NO were measured before and after treatment for two months. The result showed that the contents of hs-CRP, ET-1 in both groups reduced (P <0. 05) , while the test group show a more significant reduction than the control group (P <0. 05). After the treatment, the content of NO raised in both group, while the test group show a more significant increase than that of the control group (P <0. 05). This study indicated that Jiangzhi Kangyanghua mixture could reduce the contents of hs-CRP and ET-1 and raise NO of EH patients.
