Study on "multi-dimensional structure and process dynamics quality control system" of Danshen infusion solution based on component structure theory.
- Author:
Liang FENG
1
;
Ming-Hua ZHANG
1
;
Jun-Fei GU
1
;
Gui-You WANG
2
;
Zi-Yu ZHAO
2
;
Xiao-Bin JIA
1
Author Information
1. Key Laboratory of New Drug Delivery System of Traditional Chinese Medicine under State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China.
2. Anhui Tianyang Pharmaceutical Co., Ltd., Tianchang 239304, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Drugs, Chinese Herbal;
chemistry;
pharmacology;
standards;
Humans;
Mice;
Phenanthrolines;
chemistry;
pharmacology;
standards;
Quality Control;
Salvia miltiorrhiza;
chemistry
- From:
China Journal of Chinese Materia Medica
2013;38(21):3622-3626
- CountryChina
- Language:Chinese
-
Abstract:
As traditional Chinese medicine (TCM) preparation products feature complex compounds and multiple preparation processes, the implementation of quality control in line with the characteristics of TCM preparation products provides a firm guarantee for the clinical efficacy and safety of TCM preparation products. Danshen infusion solution is a preparation commonly used in clinic, but its quality control is restricted to indexes of finished products, which can not guarantee its inherent quality. Our study group has proposed "multi-dimensional structure and process dynamics quality control system" on the basis of "component structure theory", for the purpose of controlling the quality of Danshen infusion solution at multiple levels and in multiple links from the efficacy-related material basis, the safety-related material basis, the characteristics of dosage form to the preparation process. This article, we bring forth new ideas and models to the quality control of TCM preparation products.
