Multi-dimensional structure quality control technology system of Danmu injection based on component structural theory.
- Author:
Rong YIN
1
;
Fen-Xia ZHU
2
;
Xiu-Feng LI
3
;
Xiao-Bin JIA
2
Author Information
1. Key Laboratory of New Drug Delivery System of Traditional Chinese Medicine under State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China. yr0741428@126.com
2. Key Laboratory of New Drug Delivery System of Traditional Chinese Medicine under State Administration of Traditional Chinese Medicine, Jiangsu Provincial Academy of Chinese Medicine, Nanjing 210028, China.
3. Engineering Center for Li Nationality Medicines, Hainan Pharmaceutical Factory Co., Ltd., Wuzhishan 572200, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Chromatography, High Pressure Liquid;
Drugs, Chinese Herbal;
chemistry;
pharmacology;
standards;
Humans;
Mice;
Quality Control
- From:
China Journal of Chinese Materia Medica
2013;38(21):3632-3637
- CountryChina
- Language:Chinese
-
Abstract:
Danmu is one of common medicines in folks of Li nationality, with such effects in clearing heat and removing toxicity, antisepsis and anti-inflammation. Danmu injection, which is developed with Danmu herbs, has been clinically applied for years and showed curative efficacy. Currently, though many studies have been conducted to analyze chemical constituents in Danmu in details, its pharmacodynamic material basis related to disease prevention and treatment has not been defined. Furthermore, as the quality control methods for Danmu and its preparations remain restricted to single index component and irrational to some extent, it fails to ensure their inherent quality. On the basis of the summary of previous study results, as well as the "component structural theory" of the material basis, we established a "multi-dimensional structure quality control technology system" that is capable of reflecting the integrity of effects of Danmu injection and component structure hierarchy, and performed a dynamic monitoring over the whole process from medicinal materials and preparation products, so as to ensure the inherent quality of Danmu injection.
