Overview research of uremic ulearance granule treating chronic renal failure.
- Author:
Xian-Jie MENG
1
;
Yi-Gang WAN
2
;
Qing-Xue WEI
2
;
Hao-Li CHEN
2
;
Xi-Miao SHI
2
;
Yan-Ru HUANG
2
;
Jian YAO
2
Author Information
1. Nanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjng 210029, China. mengxianjie1314@163.com
2. Department of Traditional Chinese Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Drugs, Chinese Herbal;
therapeutic use;
Humans;
Kidney;
drug effects;
metabolism;
Kidney Failure, Chronic;
drug therapy;
genetics;
metabolism;
Oxidative Stress;
drug effects;
Transforming Growth Factor beta1;
genetics;
metabolism
- From:
China Journal of Chinese Materia Medica
2013;38(21):3651-3655
- CountryChina
- Language:Chinese
-
Abstract:
The effective bioactivity compositions of uremic clearance granul (UCG) include isoflavonoids, emodin, astragaloside, paeoniflorin, salvianolic acid A, and so on. The effects of UCG treating chronic renal failure (CRF) in clinical pharmacodynamics mainly refer to improve renal function and the complications of CRF. The mechanisms involved in vivo basically include depressing transforming growth factor (TGF)-beta1 over-expression, lessening podocyte injury,inhibiting tubular epithelial myofibroblast transdifferentiation, ameliorating microinflammation status, retarding oxidative stress, and alleviating insulin resistance.
