Preparation of the EPC and HEPC sterically stabilized doxorubicin liposomes and further studies on pharmacokinetics in rats.
- Author:
Meili YU
1
;
Yong WANG
;
Guiming SHU
;
Zhengyan ZHU
;
Shuchang FANG
;
Li WANG
Author Information
1. The Institute of Hepatology, The Third Central Hospital, Tianjin 300170, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Antibiotics, Antineoplastic;
administration & dosage;
pharmacokinetics;
Delayed-Action Preparations;
chemical synthesis;
pharmacokinetics;
Doxorubicin;
administration & dosage;
pharmacokinetics;
Drug Carriers;
chemistry;
Hydrogenation;
Liposomes;
Phosphatidylcholines;
chemistry;
pharmacology;
Rats
- From:
Journal of Biomedical Engineering
2008;25(3):597-599
- CountryChina
- Language:Chinese
-
Abstract:
In this paper, we address the preparation of the EPC and HEPC sterically stabilized doxorubicin liposomes and report the data collected from further studies on pharmacokinetics in blood for choosing a better carrier in delivering the drugs. The pharmacokinetics of EPC and HEPC sterically stabilized liposomes (EPC-SSL, and HEPC-SSL) in Wistar rats were investigated by HPLC. The results showed that the mean residence time of HEPC-SSL in blood is 23.3 h, while that of EPC-SSL is 12.0 h. In conclusion, HEPC-SSL is a better carrier in delivering the drugs to the extravascular sites when compared with EPC-SSL.
