Study on biocompatibility of hydroxyapatite/high density polyethylene (HA/HDPE) nano-composites artificial ossicle.
- Author:
Guohui WANG
1
;
Shaihong ZHU
;
Guolin TAN
;
Kechao ZHOU
;
Suping HUANG
;
Yanzhong ZHAO
;
Zhiyou LI
;
Boyun HUANG
Author Information
1. Transplantation Medical Academy, Third XiangYa Hospital, Central South University, Changsha 410013, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Biocompatible Materials;
chemistry;
Bone Substitutes;
chemistry;
Durapatite;
chemistry;
Ear Ossicles;
Female;
Implants, Experimental;
Male;
Materials Testing;
Mice;
Nanoparticles;
chemistry;
Polyethylene;
chemistry;
Swine
- From:
Journal of Biomedical Engineering
2008;25(3):607-610
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to evaluate the biocompatibility of Hydroxyapatite/High density polyethylene (HA/ HDPE) nano-composites artificial ossicle. The percentage of S-period cells were detected by flow cytometry after L929 cells being incubated with extraction of the HA/HDPE nano-composites; the titanium materials for clinical application served as the contrast. In addition, both materials were implanted in animals and the histopathological evaluations were conducted. There were no statistically significant differences between the two groups (P >0.05). The results demonstrated that the HA/HDPE nano-composite artificial ossicle made by our laboratory is of a good biocompatibility and clinical application outlook.
