Preparation and degradation of poly(DL-lactide)/calcium phosphates porous scaffolds.
- Author:
Daping QUAN
1
;
Kairong LIAO
;
Binghong LUO
;
Zejian LU
Author Information
1. Institute of Polymer Science, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.
- Publication Type:Journal Article
- MeSH:
Biocompatible Materials;
chemistry;
Bone Substitutes;
chemical synthesis;
chemistry;
Calcium Phosphates;
chemical synthesis;
chemistry;
Durapatite;
chemical synthesis;
chemistry;
Polyesters;
chemical synthesis;
chemistry;
Polymers;
chemistry;
Porosity;
Tissue Engineering
- From:
Journal of Biomedical Engineering
2004;21(2):174-177
- CountryChina
- Language:Chinese
-
Abstract:
The porous foams were prepared by the solvent-casting and particulate-leaching technique using poly(DL-lactide) (PDLLA), poly(DL-lactide)/hydroxyapatite (PDLLA/20wt%HA), and poly(DL-lactide)/beta-tricalcium phosphate(PDLLA/20wt% beta-TCP) respectively. Observations by scanning electron microscopy indicated that the HA and beta-TCP were homogeneously dispersed in the polymer matrix, and the pores of the foams are interconnected, resulting in continuous pore structures. The porosity of PDLLA/HA and PDLLA/beta-TCP foams was lower than that of the pure PDLLA foams, but the compression strength was higher than that of the pure PDLLA foams. The results of the degradation in vitro showed that both HA and beta-TCP had significant inhibitory effects on the degradation of PDLLA, especially the HA. It is expected that the composite foams are of use as scaffolds for bone tissue engineering.
