High cholesterol level upregulate the expression of caveolin-1.
- Author:
Yinwei RAN
1
;
Junrong DU
;
Bo BAI
;
Rong ZHANG
;
Zhongmin QIAN
Author Information
1. Department of Pharmacology, West China School of Pharmacy of Sichuan University, Chendu 610041, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Aorta;
pathology;
Caveolin 1;
Caveolins;
biosynthesis;
genetics;
Cells, Cultured;
Cholesterol;
blood;
Endothelium, Vascular;
cytology;
metabolism;
Female;
Humans;
Hypercholesterolemia;
metabolism;
Male;
Rabbits;
Rats;
Rats, Sprague-Dawley;
Umbilical Veins;
cytology
- From:
Journal of Biomedical Engineering
2004;21(2):276-279
- CountryChina
- Language:Chinese
-
Abstract:
To study the influence of hypercholesterolemia with caveolin-1 on the plasmalemma of vascular endothelium, we used the methods of immunohistochemistry to detect the dynamic changes of caveolin-1 in cultured ECV-304 cells which were stimulated high cholesterol serum and the arterial endothelium of hypercholesterolemia rats. It is resulted that high cholesteorol level can upregulate the expression of caveolin-1 both in vitro and in vivo. In the initial stage of hypercholesterolemia model, the expression of caveolin-1 increased as the time of high cholesterol level added, but in the later period it was decreased slightly.
