Effect of steep pulsed electric fields on survival of tumour-bearing mice.
- Author:
Chenguo YAO
1
;
Caixin SUN
;
Lan XIONG
;
Yan MI
;
Ruijin LIAO
;
Lina HU
;
Ya HU
Author Information
1. College of Electrical Engineering, Chongqing University, Chongqing, 400044, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Electrodes;
Electromagnetic Fields;
Electroporation;
Female;
Mice;
Mice, Inbred BALB C;
Neoplasm Transplantation;
Pulse;
Survival Rate;
Uterine Cervical Neoplasms;
pathology;
therapy
- From:
Journal of Biomedical Engineering
2004;21(3):433-435
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the lethal effect of steep pulsed electric fields (SPEFs) on cancer cells and the life-prolonging effect of SPEFs on the survival of tumour-bearing mice, this study was carried out with the use of SPEFs to treat 40 BALB/C mice inoculated by cervical cancer. The lethal effect on cancer cells and the life-prolonging effect on tumour-bearing mice were examined and compared between the experiment group and control group. The survival periods of the experiment group and control group were 52.05 days and 33.03 days, respectively. There was a significant difference in survival curve between the two groups. The results confirmed the inhibitiory effect and lethal effect of SPEFs on cancer cells. SPEFs can prolong the survival period of tumour-bearing mice.
