A case of mixed connective tissue disease.
- Author:
Sun Kyo SUH
;
Seok Jong LEE
;
Sang Lip CHUNG
;
Do Won KIM
- Publication Type:Original Article
- Keywords:
Mixed connective tissue disease;
Anti-RNP antibody
- MeSH:
Adult;
Antibodies, Antinuclear;
Biopsy;
DNA;
Female;
Fever;
Humans;
Immunoglobulin G;
Immunoglobulin M;
Mixed Connective Tissue Disease*;
Muscle Weakness;
Muscular Diseases;
Raynaud Disease;
Skin
- From:Korean Journal of Dermatology
1992;30(6):932-938
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
We report a case of mixed connective tissue disease. A patient, 25-year-old woman, presented Raynaud phenomenon, proximal muscle weakness, sclerodactyly, fever, and diffuse alopeeia. In the serologic examination, antinuclear antibody and anti-RNP antibody were positiv but anti-native DNA antibody was negative. In direct immunofluorescent study of biopsy specimen of the skin, speckled epidermal nuclear staining of IgG and granular deposits of IgM at the dermoepidermal junction were seen: Electromyographic finding of the right deltoid and right gastrocinemius muscle was consistent with myopathy.
