Relationship of extrahepatic metastasis of primary hepatocellular carcinoma between circulative tumor cells in the blood of hepatoma patients.
- Author:
Gang-qing ZHANG
1
;
Hong-bing WANG
;
Peng GAO
;
Chi-hua FANG
;
Gui-hua CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Carcinoma, Hepatocellular; blood; pathology; Female; Follow-Up Studies; Humans; Liver Neoplasms; blood; pathology; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging
- From: Chinese Journal of Surgery 2009;47(24):1857-1859
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relationship between extrahepatic metastasis of primary hepatocellular carcinoma and circulative tumor cells in the blood of hepatoma patients.
METHODSThe immunomagnetic bead technique was employed to enrich and separate the hepatoma cells in the peripheral blood of preoperative and postoperative hepatoma patients. The relationship between postoperative extrahepatic metastasis and hepatoma cells in peripheral blood cancer cells were analyzed. The circulative tumor cells in the peripheral blood of hepatoma patients were enriched and separated by immunomagnetic bead technique. They were identified as hepatoma cells by AFP immunohistochemistry. Among 30 cases of hepatoma patients, the positive rate of hepatoma cells in the peripheral blood of preoperation and postoperation were 53.3% and 83.3% respectively. There was difference significantly in positive cases before operation and after operation (P<0.05).
CONCLUSIONSExtrahepatic metastasis of primary hepatocellular carcinoma is obviously correlated to the positive tumor cells and the concentration in the peripheral blood of preoperative patients.
