Association between insulin-like growth factor-1 receptor gene polymorphisms and with susceptibility to adolescent idiopathic scoliosis.
- Author:
Wen-jun LIU
1
;
Yong QIU
;
Zhi-jun CHEN
;
Zhen LIU
;
Hao SHU
;
Xin-hua WANG
;
Chao SUN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Case-Control Studies; Child; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; Polymorphism, Genetic; Receptor, IGF Type 1; genetics; Scoliosis; genetics; Young Adult
- From: Chinese Journal of Surgery 2009;47(23):1813-1816
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of insulin-like growth factor-1 receptor (IGF-1R) gene polymorphisms and with susceptibility to adolescent idiopathic scoliosis (AIS).
METHODSThis study included 200 patients with AIS and 200 healthy controls. Height, menarche status, curve pattern, Cobb angle, and Risser sign in female patients were recorded. Blood samples were taken form each subject by venipuncture. Genetic DNA was extract from peripheral blood leukocytes using standard phenol/chloroform extraction. PCR-RFLP (polymerase chain reaction-restriction-fragment length polymorphism) was used for the genotyping.
RESULTThe genotype and allele frequency distribution were similar between AIS and normal control (P>0.05). The mean maximum Cobb angle, Risser sign, menarche status of different genotypes of IGF-1R gene were similar with each other among female AIS patients (P>0.05).
CONCLUSIONSThe IGF-1R gene is neither associated with the occurrence nor the curve severity of AIS.
