Intrauterine growth restriction (IUGR) associated with confined placental mosaicism of ring chromsome 15.
- Author:
Hyun Mee RYU
1
Author Information
1. Department of Obstetrics and Gynecology, Genetic Research Laboratory Samsung Cheil Hospital & Women's Health Care Center College of Medicine, Sung Kyun Kwan University, Korea.
- Publication Type:Case Report
- Keywords:
Intrauterine growth restriction;
confined placental mosaicism;
ring chromosome 15;
nuchal translucency
- MeSH:
Chromosome Aberrations;
Female;
Humans;
Karyotype;
Mosaicism*;
Nuchal Translucency Measurement;
Pregnancy;
Pregnancy Trimester, First;
Pregnancy Trimester, Third;
Sepsis
- From:Journal of Genetic Medicine
1998;2(1):7-10
- CountryRepublic of Korea
- Language:English
-
Abstract:
The present report describes a case that showed a normal fetal karyotype in an antenatal genetic study but an abnormal placental karyotype of 46,XX,r(15) on postnatal examination. The pregnancy was complicated by fetal nuchal translucency in the first trimester and intrauterine growth restriction in the second and third trimesters. A 1780 gm female baby was born after 40 weeks of gestation, but died of respiratory distress and sepsis on the 10th day of life. Our case was unique in that the placental chromosomal aberration was a structural abnormality instead of a numerical aberration that is seen in most reported cases of confined placental mosaicism.
