Duodenojejunal bypass in treatment for 7 cases with non-severe obese type 2 diabetes mellitus.
- Author:
Fei-zhao JIANG
1
;
Heng-liang ZHU
;
Xiao-feng ZHENG
;
Jin-fu TU
;
Hong LIN
;
Ru-ying HU
;
Xiong CHEN
;
He-yi YOU
;
Zhen-xu ZHOU
;
Wei-Jian ZHANG
;
Hua-Jie CAI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Bariatric Surgery; methods; Diabetes Mellitus, Type 2; surgery; Duodenum; surgery; Female; Follow-Up Studies; Humans; Jejunum; surgery; Male; Middle Aged; Obesity; Treatment Outcome
- From: Chinese Journal of Gastrointestinal Surgery 2012;15(1):36-38
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the efficacy and feasibility of duodenojejunal bypass(DJB)on non-severe obese patients with type 2 diabetes mellitus(T2DM).
METHODSThe body mass index (BMI), fasting plasma glucose(FPG), 2h-postprandial plasma glucose(2hPG), fasting insulin(F-ins), fasting c-peptide(F-CP), glycated hemoglobin and hypoglycemic agents dose changes were tested in 7 patients with non-severe obese T2DM undergoing DJB, preoperatively and within 24 weeks after surgery during the follow-up. Data were collected and the clinical outcomes of T2DM were analyzed.
RESULTSIn 7 cases of non-obese T2DM who underwent DJB, one patient was weaned off hypoglycemic agents with normal FPG, 2hPG and HbA1c postoperatively. Five required significantly lower dosage. No significant improvement in 1 case. Complete remission rate of hyperglycemia was 1/7, effective rate was 6/7, and effective rate of HbA1c was 5/7. No significant changes in BMI were observed between the preoperative and postoperative phases.
CONCLUSIONPlasma glucose level can be markedly reduced by duodenojejunal bypass in non-obese T2DM, independent of weight loss, and the mechanism remains unclear.
