Comparison of different mechanisms in the treatment of type 2 diabetes between biliopancreatic diversion and Roux-en-Y gastric bypass.
- Author:
Hong-hao WU
1
;
Hui LIANG
Author Information
1. Department of General Surgery, Nanjing Medical University, Nanjing, China.
- Publication Type:Journal Article
- MeSH:
Biliopancreatic Diversion;
Diabetes Mellitus, Type 2;
surgery;
Gastric Bypass;
Humans
- From:
Chinese Journal of Gastrointestinal Surgery
2012;15(1):88-92
- CountryChina
- Language:Chinese
-
Abstract:
A large number of clinical studies indicate that bariatric surgery leads to improvement or resolution of type 2 diabetes. The outcomes vary depending on procedure adopted. Biliopancreatic diversion(BPD) is associated with the highest cure rate(98%), followed by Roux-en-Y gastric bypass(RGBP)(80%). However, the mechanism is still unclear and controversial. The changes of many hormones after surgery are different between BPD and RGBP, especially some gastrointestinal hormones such as GLP-1 and GIP,however it cannot be fully explained by the widely known hindgut hypothesis and the foregut hypothesis. This review is intended to compare the anatomical structures and postoperative gastrointestinal hormones GLP-1 and GIP changes between the two procedures according to the latest researches in the world, and discussed different mechanisms which may take effect in improving diabetes.
