Challenges of gastrointestinal stromal tumor in the era of targeted therapy.
- Author:
Lin SHEN
1
;
Jian LI
Author Information
1. Department of Gastroenterology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Cancer Hospital and Institute, Peking University School of Oncology, Beijing 100142, China. lin100@medmail.com.cn
- Publication Type:Editorial
- MeSH:
Gastrointestinal Stromal Tumors;
drug therapy;
Humans
- From:
Chinese Journal of Gastrointestinal Surgery
2012;15(3):204-207
- CountryChina
- Language:Chinese
-
Abstract:
Targeted drugs has improved the overall survival of patients with gastrointestinal stromal tumor (GIST). However, there are some difficulties and controversies. Imatinib adjuvant therapy improves recurrence-free survival, but the treatment duration has not been determined. Furthermore, whether adjuvant therapy is beneficial to the GIST with c-kit exon 9 mutation and wild type is unclear. There are currently no prospective randomized controlled trials on the role of combination of surgery with tyrosine kinase inhibitor in patients with metastatic GIST. In addition, many challenging issues remain to be solved including patients education, side effect monitoring during sunitinib treatment, the influence of difference between the Eastern patients and the Western counterparts on sunitinib treatment schedule, and the choice of regimen after imatinib and sunitinib failure, etc. Difficulties exist in the discovery of new targets in the downstream of kit gene and the concurrent use of multiple targeted drugs. This article analyzes these problems in order to achieve a consensus and discuss future directions.
