To emphasize the importance of specimen fixation and improve quality of diagnosis of gastrointestinal stromal tumor.
- Author:
Yong-dong LIU
1
;
Wei-wei ZHAO
;
Hui-juan CHEN
;
Han-liang LIN
Author Information
1. Department of Patholgoy, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
- Publication Type:Journal Article
- MeSH:
Gastrointestinal Stromal Tumors;
diagnosis;
pathology;
Humans;
Immunohistochemistry;
Mutation;
Proto-Oncogene Proteins c-kit;
genetics;
Specimen Handling;
Staining and Labeling
- From:
Chinese Journal of Gastrointestinal Surgery
2012;15(3):234-235
- CountryChina
- Language:Chinese
-
Abstract:
The most common problem in the diagnosis of gastrointestinal stromal tumor (GIST) is inadequate specimen fixation. The paper focused on specimen fixation and standardized protocol in immunohistochemistry staining and gene mutation detection. We have adjusted some procedure used in immunohistochemistry staining and c-kit gene detection to improve the quality of inadequately fixed specimen. It maybe useful for clinicians, pathologists and technicians working in immunohistochemistry labs and gene detection labs.
