Preparation of elastic porous cell scaffold fabricated with combined polydimethylsiloxane (PDMS) and hydroxyapatite (HA).
- Author:
Yang YANG
;
Ding LAN
;
Yan HUANG
;
Yanming LI
;
Yuren WANG
;
Lianwen SUN
;
Yubo FAN
- Publication Type:Journal Article
- MeSH:
Animals;
Biocompatible Materials;
chemistry;
Dimethylpolysiloxanes;
chemistry;
Durapatite;
chemistry;
Mesenchymal Stromal Cells;
cytology;
Porosity;
Rats;
Tissue Scaffolds
- From:
Journal of Biomedical Engineering
2014;31(3):625-631
- CountryChina
- Language:Chinese
-
Abstract:
Polydimethylsiloxane (PDMS) and hydroxyapatite (HA) were combined in our laboratory to fabricate an elastic porous cell scaffold with pore-forming agent, and then the scaffold was used as culture media for rat bone marrow derived mesenchymal stem cells (rBMSCs). Different porous materials (square and circular in shape) were prepared by different pore-forming agents (NaCl or paraffin spheres) with adjustable porosity (62%-76%). The HA crystals grew on the wall of hole when the material was exposed to SBF solutions, showing its biocompatibility and ability to support the cells to attach on the materials.
