The Expression of CD44s, CD44v5, CD44v6, p27(kip1) in Colorectal Carcinoma.
- Author:
In Chull JUNG
1
;
Ki Hong KIM
;
Young Jin PARK
;
Byung Joo SONG
;
Myung Soo LEE
;
Chul Nam KIM
;
Seok Hyo CHANG
;
Jong Man WON
;
Ji Il KIM
Author Information
1. Department of Surgery, College of Medicine, Inje University, Ilsan Paik Hospital, Ilsan, Korea. jikim@ilsanpaik.ac.kr
- Publication Type:Original Article
- Keywords:
Colorectal carcinoma;
CD44;
p27(kip1)
- MeSH:
Classification;
Colorectal Neoplasms*;
Disease Progression;
Lymph Nodes;
Lymphatic System;
Neoplasm Metastasis;
Prognosis;
Recurrence
- From:Journal of the Korean Surgical Society
2002;62(4):319-326
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: In treating colorectal carcinoma, metastasis and recurrence are the most important problems encountering after a curative resection of the tumor. Therefore, understanding the mechanism of the disease progression and being able to predict the likelihood of recurrence is very important. METHODS: In this study, 56 colorectal carcinoma cases were reviewed. Immunohistochemical staining on CD44s, CD44v5, CD44v6, and p27(kip1) were performed to determine the expression level of the protein, the patient's clinical findings and the pathophysiology. RESULTS: 1) CD44v5 showed a positive response in 47 (83.9%) out of 56 cases. By analyzing the Astler-Coller classification and the invasion of the lymphatic system, the value expressed was significantly high. 2) p27(kip1) showed a positive response in 35 (62.5%) out of 56 cases. As the disease progressed, there was a significant decrease according to analysis of Astler-Coller classification, and the invasion of the lymph node and lymphatics. The relationship showed an inverse correlation as the disease progressed. 3) For the CD44s and CD44v6, analysis by the Astler-Coller classification, the histological pattern, lymph node metastasis, invasion of the lymphatic system and the depth of the invasion, were not significantly different. CONCLUSION: CD44v5 and p27(kip1) have a relationship with tumor progression, and is a valuable marker for prognosis. In particular, CD44v5 appeared to be involved in tumor progression where the tumor cells invaded the lymphatic system.
