Efficacy of Vancomycin-beta-lactam Combinations Against Heterogeneously Vancomycin-Resistant Staphylococcus aureus (hetero-VRSA).
10.3346/jkms.2003.18.3.319
- Author:
Yeon Sook KIM
1
;
Sungmin KIEM
;
Hwan Jung YUN
;
Sook In JUNG
;
Won Sup OH
;
Shin Woo KIM
;
Kyong Ran PECK
;
Nam Yong LEE
;
Jae Hoon SONG
Author Information
1. Department of Internal Medicine, Chungnam National University Hospital, Daejeon, Korea.
- Publication Type:Original Article ; In Vitro ; Research Support, Non-U.S. Gov't
- Keywords:
Vancomycin;
Vancomycin Resistance;
Antibiotics Lactam;
Oxacillin;
Cefotaxime;
Staphy-lococcus aureus
- MeSH:
Anti-Bacterial Agents/*pharmacology;
Cefotaxime/pharmacology;
Drug Synergism;
Human;
In Vitro;
Microbial Sensitivity Tests;
Oxacillin/*pharmacology;
Staphylococcus aureus/*drug effects;
Vancomycin/*pharmacology;
Vancomycin Resistance;
beta-Lactam Resistance
- From:Journal of Korean Medical Science
2003;18(3):319-324
- CountryRepublic of Korea
- Language:English
-
Abstract:
There have been conflicting data about the interactions between vancomycin and beta-lactam agents against Staphylococcus aureus strains with heterogeneous resistance to vancomycin. We evaluated the efficacy of these combinations against Mu 3 and heterogeneously vancomycin-resistant S. aureus (hetero-VRSA) strains which were isolated from Korean patients using a population analysis method. Antagonistic effects were observed when less than 1 g/mL of beta-lactam antibiotics was combined with vancomycin, whereas synergistic effects were noticed with more than 4 microgram/mL of beta-lactam antibiotics. The antagonistic effects at low concentrations of beta-lactams were most prominent at 2 microgram/mL of vancomycin, which were the vancomycin MICs of tested hetero-VRSA strains. This study showed the variable effects of vancomycin- beta-lactam combinations depending on the concentrations of beta-lactam antibiotics and this property could be used to develop screening methods for hetero-VRSA strains.
