Relationship between the polymorphisms of UGT1A6 genes and anti-tuberculosis drug induced hepatic-injury.
- Author:
Jin-qi HAO
1
;
Yi CHEN
;
Shi-ming LI
;
Peng ZHANG
;
Yan-qin YU
;
Gui-yu TANG
;
Fu-min FENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Antitubercular Agents; adverse effects; Case-Control Studies; Chemical and Drug Induced Liver Injury; genetics; Female; Genotype; Glucuronosyltransferase; genetics; Humans; Liver; pathology; Male; Middle Aged; Polymorphism, Genetic; Tuberculosis, Pulmonary; drug therapy
- From: Chinese Journal of Hepatology 2011;19(3):201-204
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between the polymorphisms of UGT1A6 genes and anti-tuberculosis drug induced hepatic-injury (ADIH).
METHODS202 cases and 239 controls were collected and a case-control study was conducted. Information on related risk factors of tuberculosis was collected. The genotypes of UGT1A6-19T/G, UGT1A6-308C/A and UGT1A6-541A/G genetic polymorphisms were detected by polymerase chain reaction and restriction fragment length polymorphism technique (PCR-RFLP) in patients received anti-tuberculosis therapy. The Hha I, Dpn II and Nsi I enzyme were employed. Univariate and multivariate conditional logistic analyses were conducted using SPSS13.0 for windows software.
RESULTS
RESULTSThe allele frequency of gene UGT1A6-19T/T, UGT1A6-19T/G, UGT1A6-19G/G, GT1A6-308C/C, UGT1A6-308C/A, UGT1A6-308A/A, UGT1A6-541AA, UGT1A6-541A/G and UGT1A6-541G/G in ADIH group were 51.5%, 39.6%, 8.9%, 52.0%, 40.6%, 7.4%, 57.9%, 33.7%, 8.4% and 71.1%, 25.5%, 3.3%, 79.1%, 19.2%, 1.7%, 79.5%, 19.2%, 1.3% in control group, respectively. Univariate analysis demonstrated that the frequency of UGT1A6-19T/G, UGT1A6-308C/A and UGT1A6-541A/G genotype in cases were significantly higher than that in controls (P less than 0.05).
CONCLUSIONA positive association is found between UGT1A6 genotype and the occurrence of ADIH. The synergetic effect is proved on susceptibility to pulmonary tuberculosis between UGT1A6 mutant genotypes.
