Pleomorphism of the myelin-like bodies in the hepatocytes of patients with Dubin-Johnson syndrome complicated with chronic hepatitis B.
- Author:
Xiao-Bo LU
1
;
Hao LIU
;
Qin XU
;
Yue-Xin ZHANG
;
Ze-Run DENG
;
An-Hua HU
;
Wen-Jie LIU
;
Rong-Fu LV
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Female; Hepatitis B, Chronic; complications; pathology; Hepatocytes; chemistry; pathology; ultrastructure; Humans; Jaundice, Chronic Idiopathic; complications; pathology; Male; Myelin Sheath; ultrastructure; Young Adult
- From: Chinese Journal of Hepatology 2011;19(3):210-213
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore characteristics of the myelin-like bodies in the hepatocytes of patients with Dubin-Johnson syndrome (DJS) complicated with chronic hepatitis B (CHB).
METHODS11 cases of DJS complicated with CHB and 5 cases DJS without CHB were studied clinicopathologically. The hepatocyte ultrastructure was observed with transmission electron microscope and taken photos. The data were compared and analyzed using Fisher's Exact Test.
RESULTSDeposition of myelin-like bodies can be observed in the hepatocytes of DJS patients with CHB but can not in DJS patients without CHB. The morphology of pigment varys. The electron density and volume of pigment in DJS patients with CHB can be classified into five types: brights (2/11,18.2%), reticulation (1/11, 9.1%), punctiform (6/11, 54.5%), abnormity (1/11, 9.1%) and primary type (1/11, 9.1%). The myelin-like bodies in the hepatocytes of patients with DJS are high density and round with membrance (we named it as primary type) (5/5, 100%).
CONCLUSIONSThe myelin-like bodies in the hepatocytes of DJS patients with CHB possess special pleomorphism and may have important diagnostic value.
