PD-1/PD-L1 expressions in liver tissues of patients with chronic HBV infection.
- Author:
Xiao-ying TENG
1
;
Peng WANG
;
Xin-gang ZHOU
;
Bing SHEN
;
Lei SUN
;
Zhen-wei LANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Antigens, CD; metabolism; B7-H1 Antigen; metabolism; CD8-Positive T-Lymphocytes; metabolism; Female; Hepatitis B, Chronic; metabolism; pathology; Humans; Immunohistochemistry; Liver; metabolism; pathology; Male; Middle Aged; Programmed Cell Death 1 Receptor; metabolism
- From: Chinese Journal of Hepatology 2011;19(5):345-348
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect and compare the PD-1/PD-L1 (programmed death 1/programmed death 1 ligand) expressions in the liver tissues of chronic HBV infection patients in immune tolerant phase and those in immune clearance phase.
METHODSLiver biopsy samples were divided into two groups: 25 samples from patients in immune clearance phase and 19 samples from patients in immune tolerant phase. PD-1/PD-L1 expressions on T lymphocytes in these liver biopsy specimens were detected by immunohistochemistry method. Percentage of PD-1/PD-L1 positive cells among CD3 positive cells was calculated by semi-quantitative evaluation. Differences between the two groups were statistically analyzed.
RESULTSPD-1/PD-L1 expressions were significantly higher in the patients in immune tolerant phase as compared to that in immune active phase (P < 0.05). No statistical difference found between the two groups for PD-L1 expression in Kupffer cells (P > 0.05).
CONCLUSIONPD-1/PD-L1 expression level can reflect the immune functions of chronic hepatitis B patients.
