The effect of nitric oxide/endothelins system on the hepatic ischemia/reperfusion injury.
- Author:
Ping LÜ
1
;
Daoda CHEN
;
Yuan TIAN
;
Jinghui ZHANG
;
Yihua WU
Author Information
1. Department of General Surgery, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.
- Publication Type:Journal Article
- MeSH:
Animals;
Arginine;
Endothelin Receptor Antagonists;
Endothelins;
blood;
Female;
Liver;
blood supply;
Male;
NG-Nitroarginine Methyl Ester;
Nitric Oxide;
blood;
Rats;
Reperfusion Injury;
blood
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2002;22(3):216-227
- CountryChina
- Language:English
-
Abstract:
The relationship between the hepatic ischemia/reperfusion (I/R) injury and the balance of nitric oxide/endothelins (NO/ET) was studied. The changes of the ratio of NO/ET and the hepatic injury were observed in a rat hepatic I/R model pretreated with several tool drugs. In the acute phase of hepatic I/R injury, the ratio of plasma NO/ET was reduced from 1.58 +/- 0.20 to 0.29 +/- 0.05 (P < 0.01) and the hepatic damage deteriorated. NO donor L-Arg and ET receptor antagonist TAK-044 could alleviate the hepatic I/R injury to some degree, whereas NO synthase inhibitor L-NAME aggravated the damage. It was concluded that the hepatic I/R injury might be related with the disturbance of the NO/ET balance. Regulation of this balance might have an effect on the I/R injury.
