The expression of the apoptosis-suppressive gene bcl-2 in the tissue of colon carcinoma.
- Author:
Wenguang HUANG
1
;
Xuan YAO
Author Information
1. Department of General Surgery, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.
- Publication Type:Journal Article
- MeSH:
Adenocarcinoma;
genetics;
pathology;
Adult;
Apoptosis;
genetics;
Colonic Neoplasms;
genetics;
pathology;
Female;
Humans;
Male;
Middle Aged;
Neoplasm Staging;
Proto-Oncogene Proteins c-bcl-2;
biosynthesis;
genetics;
Rectal Neoplasms;
genetics;
pathology
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2002;22(3):218-220
- CountryChina
- Language:English
-
Abstract:
The role of bcl-2 in the pathogenesis of colorectal tumor were studied. The expression of bcl-2 in the colorectal carcinoma and incisional edge tissue of tumor was detected by using SABC method. The results showed that the positive rate of bcl-2 was 69.6% in colorectal carcinoma and 47.6% in the incisional edge tissue respectively, with the difference being very significant (P = 0.001). Bcl-2 positive rate was associated with Dukes' stage, but had nothing to do with histological classification. It was concluded that bcl-2 might play a significant role in the development of colorectal carcinoma.
