Possible association of HLA-DRB1 gene with the autoantibody against myocardial mitochondria ADP/ATP carrier in dilated cardiomyopathy.
- Author:
Qiufen WANG
1
;
Yuhua LIAO
;
Feili GONG
;
Huanyuan MAO
;
Jinzhi ZHANG
Author Information
1. Cardiology Department, Institute of Cardiovascular Disease, Tongji Medical University, Wuhan 430022.
- Publication Type:Journal Article
- MeSH:
Adult;
Autoantibodies;
immunology;
Cardiomyopathy, Dilated;
genetics;
immunology;
Female;
HLA-DR Antigens;
genetics;
immunology;
HLA-DRB1 Chains;
Humans;
Male;
Middle Aged;
Mitochondria, Heart;
immunology;
Mitochondrial ADP, ATP Translocases;
immunology
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2002;22(3):231-245
- CountryChina
- Language:English
-
Abstract:
To probe the genetic background and immunopathogenesis of dilated cardiomyopathy (DCM) 77 patients with DCM, HLA-DRB1 gene polymorphism were analyzed by using the polymerase chain reaction/sequence specific primer (PCR/SSP) technique and autoantibody against myocardial mitochondria ADP/ATP carrier were examined by using the Immunoblot analysis. The frequency of HLA-DRB1*0901 allele was significantly higher in DCM patients in which autoantibody against ADP/ATP carrier of myocardial mitochondria is positive in contrast with those in which the autoantibody is negative (25.46% vs 3.45%, P < 0.05), the relative risk (RR) being 9.56. The other frequencies of HLA-DRB1 alleles have no significant difference in the antibody positive group and negative group. It is possible that a subset of DCM patients may exist in which autoimmunity is associated with genetic factors.
