Peroxisome proliferator-activated receptor-gamma activated by ligands can inhibit human lung cancer cell growth through induction of apoptosis.
- Author:
Min ZHANG
1
;
Ping ZOU
;
Ming BAI
;
Yang JIN
;
Xiaonan TAO
Author Information
1. Institute of Hematology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
pharmacology;
Apoptosis;
drug effects;
Carcinoma, Non-Small-Cell Lung;
pathology;
Carcinoma, Small Cell;
pathology;
Cell Division;
drug effects;
Gene Expression Regulation, Neoplastic;
Humans;
Ligands;
Lung Neoplasms;
pathology;
Prostaglandin D2;
analogs & derivatives;
pharmacology;
Receptors, Cytoplasmic and Nuclear;
agonists;
metabolism;
Transcription Factors;
agonists;
metabolism;
Tumor Cells, Cultured
- From:
Journal of Huazhong University of Science and Technology (Medical Sciences)
2003;23(2):138-140
- CountryChina
- Language:English
-
Abstract:
To study the expression of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) in lung cancer cells, and to testify if the PPAR-gamma agonists can inhibit human lung cancer cell growth through induction of apoptosis, PPAR-gamma was detected in two lung cancer cell lines by RT-PCR and immunohistochemistry, the inhibition of human lung cancer cell growth was investigated by MTT and cell counts, and the apoptosis was assessed by TUNEL. The results showed that: (1) PPAR-gamma expressed on two lung cancer cell lines; (2) PPAR-gamma activated by ligands could inhibit human lung cancer cell growth remarkably; (3) PPAR-gamma agonists could induce apoptosis to inhibit lung cancer cell growth. It was concluded that PPAR-gamma expressed in lung cancer cell can be activated by ligands and can inhibit lung cancer cell growth through induction of apoptosis.
