Clinical significance of high-sensitivity C-reactive protein in development of chronic hepatitis B.
- Author:
Lina MA
1
;
Xiaoyan LIU
;
Yanchao HU
;
Xia LUO
;
Yuanyuan TANG
;
Jinliang PAN
;
Shuaiwei LIU
;
Xiangchun DING
Author Information
- Publication Type:Journal Article
- MeSH: Alanine Transaminase; Aspartate Aminotransferases; C-Reactive Protein; Hepatitis B virus; Hepatitis B, Chronic; Humans; Liver Cirrhosis
- From: Chinese Journal of Hepatology 2015;23(7):498-501
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the clinical significance of high-sensitivity C-reactive protein (hsCRP) in the development of chronic hepatitis B (CHB).
METHODSA total of 182 patients with untreated CHB and 50 healthy individuals (controls) participated in the study. Correlation analysis was performed to determine the association of serum hs-CRP with the age,sex,medical history,serum hepatitis B virus (HBV) DNA, liver function parameters,liver stiffness measure (LSM) and hepatic fibrosis; in addition, correlation analysis was carried out for the associations of degree of liver damage with grade of hepatic fibrosis, LSM and the serum levels of hs-CRP.
RESULTSCHB patients showed significantly higher serum hs-CRP levels than healthy controls (2.38 ± 2.79 vs.0.78 ± 1.07; t =2.495, P < 0.05). Serum hs-CRP levels were significantly correlated with HBV DNA (r = 0.159), liver function parameters (total bilirubin, r = 0.271; alanine aminotransferase, r = 0.298; aspartate aminotransferase, r = 0.389), and LSM, r = 0.562) (all P < 0.05). The correlations with liver function (r = 0.340), LSM (r = 0.292) and hepatic fibrosis grade were positive (r = 0.434) (all P < 0.01).
CONCLUSIONSerum hs-CRP levels in CHB patients can reflect degree of liver damage and of liver fibrosis.
