Endothelial dysfunction in patients with obstructive sleep apnoea independent of metabolic syndrome.
- Author:
Babak AMRA
1
;
Elaheh KARBASI
;
Mohammad HASHEMI
;
Birgit HOFFMANN-CASTENDIEK
;
Mohammad GOLSHAN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Case-Control Studies; Endothelium, Vascular; diagnostic imaging; physiopathology; Female; Humans; Male; Metabolic Syndrome; Middle Aged; Sleep Apnea, Obstructive; complications; Ultrasonography; Young Adult
- From:Annals of the Academy of Medicine, Singapore 2009;38(5):461-464
- CountrySingapore
- Language:English
-
Abstract:
INTRODUCTIONObstructive sleep apnoea syndrome (OSAS), characterised by intermittent hypoxia/re-oxygenation, has been identified as an independent risk factor for cardiovascular diseases and endothelial dysfunction. Our aim was to investigate flow-mediated dilatation (FMD) in patients with obstructive sleep apnoea with and without metabolic syndrome.
MATERIALS AND METHODSFifty-two subjects with OSAS diagnosed by polysomnography were classified into 2 groups according to the presence and absence of the metabolic syndrome and also according to the severity: mild to moderate OSAS group and severe OSAS group. Endothelial function of the brachial artery was evaluated by using high-resolution vascular ultrasound. Endothelial-dependent dilatation (EDD) was assessed by establishing reactive hyperaemia and endothelial-independent dilatation (EID) was determined by using sublingual isosorbide dinitrate. Spearman correlation and regression analysis were performed.
RESULTSEDD was not significantly different in patients with OSAS and metabolic syndrome as compared with OSAS without metabolic syndrome (4.62 +/- 0.69 versus 4.49 +/- 0.93, P >0.05).
CONCLUSIONSEndothelial dysfunction in OSA may be independent of metabolic syndrome.
