A practical guide for multivariate analysis of dichotomous outcomes.
- Author:
James LEE
1
;
Chuen Seng TAN
;
Kee Seng CHIA
Author Information
1. University of Hawaii, USA.
- Publication Type:Journal Article
- MeSH:
Cross-Sectional Studies;
Humans;
Incidence;
Models, Statistical;
Multivariate Analysis;
Odds Ratio;
Outcome Assessment (Health Care);
methods;
Poisson Distribution;
Prevalence;
Proportional Hazards Models;
Risk;
Risk Assessment
- From:Annals of the Academy of Medicine, Singapore
2009;38(8):714-719
- CountrySingapore
- Language:English
-
Abstract:
A dichotomous (2-category) outcome variable is often encountered in biomedical research, and Multiple Logistic Regression is often deployed for the analysis of such data. As Logistic Regression estimates the Odds Ratio (OR) as an effect measure, it is only suitable for case-control studies. For cross-sectional and time-to-event studies, the Prevalence Ratio and Cumulative Incidence Ratio can be estimated and easily interpreted. The logistic regression will produce the OR which is difficult to interpret in these studies. In this report, we reviewed 3 alternative multivariate statistical models to replace Logistic Regression for the analysis of data from cross-sectional and time-to-event studies, viz, Modified Cox Proportional Hazard Regression Model, Log-Binomial Regression Model and Poisson Regression Model incorporating the Robust Sandwich Variance. Although none of the models is without flaws, we conclude the last model is the most viable. A numeric example is given to compare the statistical results obtained from all 4 models.
