Effects of cholesterol ester transfer protein Taq1B polymorphism on response of serum HDL-C to dietary factors in hyperlipidemia patients.
- Author:
Zhen-hui XU
1
;
Hong-wei GUO
;
Zhu-ying HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Cholesterol Ester Transfer Proteins; genetics; Cholesterol, HDL; blood; Diet; Disease Susceptibility; Female; Gene Frequency; Genotype; Humans; Hyperlipidemias; blood; genetics; Male; Middle Aged; Polymorphism, Single Nucleotide
- From: Chinese Journal of Preventive Medicine 2006;40(4):269-272
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the effects of cholesterol ester transfer protein (CETP) Taq1B polymorphism on the response of serum HDL-C to dietary factors in hyperlipidemia patients.
METHODSAll 141 hyperlipidemia residents in a community in Shanghai were investigated by a 3-day diet questionnaire. The serum lipids were analyzed, and the polymorphism of CETP gene was detected by PCR-RFLP method. The correlation between dietary factors and serum HDL-C in different genotype was analyzed when considering the effects of sex, age and body mass index.
RESULTThe HDL-C of hyperlipidemia patients was affected by dietary factors and CETP gene Taq1B polymorphism. The strength of the correlation between dietary factors and serum HDL-C was different among the genotype groups. The relation was shown closer in B(2)B(2) subjects than in B(1)B(1).
CONCLUSIONThe Taq1B CETP gene polymorphism should be a strong determinant of HDL-C in hyperlipidemia patients, and might contribute to the heterogeneity in HDL-C response to dietary intervention.
