Relationship between quinone oxidoreductase1 gene ns-cSNP and genetic susceptibility of esophageal cancer.
- Author:
Wen-cui ZHANG
1
;
Li-hong YIN
;
Yue-pu PU
;
Ge-yu LIANG
;
Xu HU
;
Yao-zhen LIU
;
Yong-sheng CUI
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; China; Esophageal Neoplasms; ethnology; genetics; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; NAD(P)H Dehydrogenase (Quinone); genetics; Polymorphism, Single Nucleotide
- From: Chinese Journal of Preventive Medicine 2006;40(5):324-327
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between quinone oxidoreductase1 (NQO1) gene nonsynonymous cSNP and the genetic susceptibility of esophageal cancer.
METHODSPolymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and Allele-Specific PCR (AS-PCR) were employed to assess the polymorphism of NQO1 genes both in 106 patients with esophageal cancer and control subjects matched by age, gender and origin.
RESULTSIt was shown that no C/C genotype was found at 406 of NQO1. The allelic frequency of NQO1 609T was significantly higher in patients with esophageal cancer than in the control subjects (P < 0.005) and the individuals with 609T allelic genotype of NQO1 gene were at greater risk to develop esophageal cancer (OR = 4.76, 95% CI = 1.064 - 3.397). But Individuals with mutant allele of NQO1 465 genotype did not show the rising risk of esophageal cancer.
CONCLUSIONSThe NQO1 C609T polymorphisms should likely be associated with the genetic susceptibility of esophageal cancer.
